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(Generic Wellbutrin®)

Disclaimer: This is not meant to be medical advice, and always discuss with your care manager, prescriber or other doctor before making any medication changes or taking action, unless otherwise indicated. Please refer to the package insert included with your medication.

What is Bupropion?

Bupropion is a prescription medication used to treat depression and has evidence for treating ADHD. It is also used to help people stop smoking. It works by increasing dopamine and norepinephrine levels in the brain. There is a large body of scientific evidence that supports Bupropion’s use as very safe and effective antidepressant. One of the unique aspects of bupropion is that it works on dopamine and to some extent, norepinephrine, which makes it unique compared to the SSRIs which focus on serotonin. Importantly, Bupropion is not a stimulant or a controlled substance.

How does Bupropion work?

Bupropion is thought to work principally by increasing levels of dopamine and norepinephrine in certain parts of the brain, though it has effects on other neurotransmitters as well. Because of this mechanism of action, bupropion has been proven to be an effective treatment for patients with ADHD, especially those who also have depressive symptoms.

How long does it take for Bupropion to work?

For depression: Some people notice improvement within the first week, but it takes 2-4 weeks to get the full effect of a given dosage. If you do not experience improvement by 8 weeks, the dosage of the medication may need to be increased or a different medication tried. 

For ADHD: Similarly, while some patients may experience an improvement earlier, Bupropion may take up to 2 to 4 weeks to improve symptoms of ADHD. 

What types of Bupropion are there?

Bupropion comes in tablets, including a regular Bupropion tablet, a Bupropion SR table (sustained release), Bupropion XL tablet (extended release) and as Bupropion hydrobromide extended release tablet. 

How do I take Bupropion?

Bupropion is best taken in the morning. Taking it later in the day may cause insomnia. Bupropion can be taken with or without food.

What if I miss a dose? 

If it is almost time for your next dose, skip the missed dose and go back to taking at your normal time. Do not take 2 doses at the same time or extra doses. If you find yourself consistently missing your medication, let your Mantra-affiliated provider know.

Can I take while drinking?

While there is no absolute rule that you cannot drink with Bupropion , there is some evidence that drinking alcohol with Bupropion may increase your risk of seizures. This is particularly important if you are a heavy drinker, as a heavy drinker who suddenly stops drinking when starting treatment on Bupropion is at risk for seizures. Alcohol tolerance may also decrease, so 1 or 2 drinks may feel like 2 or 3, for example. Always discuss alcohol consumption with your Mantra-affiliated provider to understand the risks of drinking or abruptly changing your drinking pattern while on Bupropion.

Can I take Bupropion other medications?

You can take most medications with Bupropion , however there are some very important and potentially serious interactions that your provider needs to be aware of. It is important that you let them know all of the medications, herbs and supplements you are taking. Please see below in the ‘side effects’ section for some examples of medications that can have significant interactions with Bupropion.

Should I take Bupropion when I’m pregnant or breastfeeding?

If you are pregnant or breastfeeding or plan to become pregnant, let your Mantra-affiliated provider know. As with many medications, deciding whether to continue treatment requires a careful, individualized discussion of the risks and benefits of treatment. 

Important Safety Information

All medications have risks. While most of the side effects from Bupropion are either mild or very rare, you should discuss the risks and benefits of the medication. If you experience any side effects, please notify your provider immediately. If you have a serious side effect, contact your in-person health care provider immediately. If you are having an emergency, call 911 or go to your nearest emergency room.

Read this Medication Guide carefully before you start using WELLBUTRIN and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. If you have any questions about WELLBUTRIN, ask your doctor or pharmacist.

IMPORTANT: Be sure to read the three sections of this Medication Guide. The first section is about the risk of suicidal thoughts and actions with antidepressant medicines; the second section is about the risk of changes in thinking and behavior, depression and suicidal thoughts or actions with medicines used to quit smoking; and the third section is entitled “What Other Important Information Should I Know About WELLBUTRIN?”

Antidepressant Medicines, Depression and Other Serious Mental Illnesses, and Suicidal Thoughts or Actions

This section of the Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Talk to your, or your family member’s, healthcare provider about:

  • all risks and benefits of treatment with antidepressant medicines
  • all treatment choices for depression or other serious mental illness

What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions?

1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.

2. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions.

3. How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?

  • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
  • Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings.
  • Keep all follow-up visits with the healthcare provider as scheduled. Call the healthcare provider between visits as needed, especially if you have concerns about symptoms.

Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • trouble sleeping (insomnia)
  • attempts to commit suicide
  • new or worse irritability
  • new or worse depression
  • acting aggressive, being angry, or violent
  • new or worse anxiety
  • acting on dangerous impulses
  • feeling very agitated or restless
  • an extreme increase in activity and talking (mania)
  • panic attacks
  • other unusual changes in behavior or mood

What else do I need to know about antidepressant medicines?

  • Never stop an antidepressant medicine without first talking to a healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms.
  • Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.
  • Antidepressant medicines have other side effects. Talk to the healthcare provider about the side effects of the medicine prescribed for you or your family member.
  • Antidepressant medicines can interact with other medicines. Know all of the medicines that you or your family member takes. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider.
  • Not all antidepressant medicines prescribed for children are FDA approved for use in children. Talk to your child’s healthcare provider for more information.

WELLBUTRIN has not been studied in children under the age of 18 and is not approved for use in children and teenagers.

Quitting Smoking, Quit-Smoking Medications, Changes in Thinking and Behavior, Depression, and Suicidal Thoughts or Actions

This section of the Medication Guide is only about the risk of changes in thinking and behavior, depression and suicidal thoughts or actions with drugs used to quit smoking.

Although Wellbutrin is not a treatment for quitting smoking, it contains the same active ingredient (bupropion hydrochloride) as ZYBAN® which is used to help patients quit smoking.

Some people have had changes in behavior, hostility, agitation, depression, suicidal thoughts or actions while taking bupropion to help them quit smoking. These symptoms can develop during treatment with bupropion or after stopping treatment with bupropion.

If you, your family member, or your caregiver notice agitation, hostility, depression, or changes in thinking or behavior that are not typical for you, or you have any of the following symptoms, stop taking bupropion and call your healthcare provider right away:

  • thoughts about suicide or dying
  • an extreme increase in activity and talking (mania)
  • attempts to commit suicide
  • abnormal thoughts or sensations
  • new or worse depression
  • seeing or hearing things that are not there
  • new or worse anxiety (hallucinations)
  • panic attacks
  • feeling people are against you (paranoia)
  • feeling very agitated or restless
  • feeling confused
  • acting aggressive, being angry, or violent
  • other unusual changes in behavior or mood
  • acting on dangerous impulses

When you try to quit smoking, with or without bupropion, you may have symptoms that may be due to nicotine withdrawal, including urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, and increased appetite or weight gain. Some people have even experienced suicidal thoughts when trying to quit smoking without medication. Sometimes quitting smoking can lead to worsening of mental health problems that you already have, such as depression.

Before taking bupropion, tell your healthcare provider if you have ever had depression or other mental illnesses. You should also tell your doctor about any symptoms you had during other times you tried to quit smoking, with or without bupropion.

What Other Important Information Should I Know About Wellbutrin?

Seizures: There is a chance of having a seizure (convulsion, fit) with Wellbutrin, especially in people:

  • with certain medical problems.
  • who take certain medicines.

The chance of having seizures increases with higher doses of Wellbutrin. For more information, see the sections “Who should not take Wellbutrin?” and “What should I tell my doctor before using Wellbutrin?” Tell your doctor about all of your medical conditions and all the medicines you take. Do not take any other medicines while you are using Wellbutrin unless your doctor has said it is okay to take them.

If you have a seizure while taking Wellbutrin, stop taking the tablets and call your doctor right away. Do not take Wellbutrin again if you have a seizure.

  • High blood pressure (hypertension). Some people get high blood pressure, that can be severe, while taking Wellbutrin. The chance of high blood pressure may be higher if you also use nicotine replacement therapy (such as a nicotine patch) to help you stop smoking.
  • Severe allergic reactions. Some people have severe allergic reaction to Wellbutrin. Stop taking Wellbutrin and call your doctor right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.
  • Unusual thoughts or behaviors. Some patients have unusual thoughts or behaviors while taking Wellbutrin, including delusions (believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or feeling confused. If this happens to you, call your doctor.

What is Wellbutrin?

Wellbutrin is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder.

Who should not take Wellbutrin?

Do not take Wellbutrin if you

  • have or had a seizure disorder or epilepsy.
  • are taking ZYBAN (used to help people stop smoking) or any other medicines that contain bupropion hydrochloride, such as Wellbutrin SR Sustained-Release Tablets or Wellbutrin XL Extended-Release Tablets. Bupropion is the same ingredient that is in Wellbutrin.
  • drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines and you stop using them all of a sudden.
  • have taken within the last 14 days medicine for depression called a monoamine oxidase inhibitor (MAOI), such as NARDIL®* (phenelzine sulfate), PARNATE® (tranylcypromine sulfate), or MARPLAN®* (isocarboxazid).
  • have or had an eating disorder such as anorexia nervosa or bulimia.
  • are allergic to the active ingredient in Wellbutrin, bupropion, or to any of the inactive ingredients. See the end of this leaflet for a complete list of ingredients in Wellbutrin.

What should I tell my doctor before using Wellbutrin?

Tell your doctor if you have ever had depression, suicidal thoughts or actions, or other mental health problems. See “Antidepressant Medicines, Depression and Other Serious Mental Illnesses, and Suicidal Thoughts or Actions.”

Tell your doctor about your other medical conditions including if you:

  • are pregnant or plan to become pregnant. It is not known if Wellbutrin can harm your unborn baby.
  • are breastfeeding. Wellbutrin passes through your milk. It is not known if Wellbutrin can harm your baby.
  • have liver problems, especially cirrhosis of the liver.
  • have kidney problems.
  • have an eating disorder, such as anorexia nervosa or bulimia.
  • have had a head injury.
  • have had a seizure (convulsion, fit).
  • have a tumor in your nervous system (brain or spine).
  • have had a heart attack, heart problems, or high blood pressure.
  • are a diabetic taking insulin or other medicines to control your blood sugar.
  • drink a lot of alcohol.
  • abuse prescription medicines or street drugs.
  • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Many medicines increase your chances of having seizures or other serious side effects if you take them while you are using Wellbutrin.

How should I take Wellbutrin?

  • Take Wellbutrin exactly as prescribed by your doctor.
  • Take Wellbutrin at the same time each day.
  • Take your doses of Wellbutrin at least 6 hours apart.
  • You may take Wellbutrin with or without food.
  • If you miss a dose, do not take an extra tablet to make up for the dose you forgot. Wait and take your next tablet at the regular time. This is very important. Too much Wellbutrin can increase your chance of having a seizure.
  • If you take too much Wellbutrin, or overdose, call your local emergency room or poison control center right away.
  • Do not take any other medicines while using Wellbutrin unless your doctor has told you it is okay.
  • It may take several weeks for you to feel that Wellbutrin is working. Once you feel better, it is important to keep taking Wellbutrin exactly as directed by your doctor. Call your doctor if you do not feel Wellbutrin is working for you.
  • Do not change your dose or stop taking Wellbutrin without talking with your doctor first.

What should I avoid while taking Wellbutrin?

  • Do not drink a lot of alcohol while taking Wellbutrin. If you usually drink a lot of alcohol, talk with your doctor before suddenly stopping. If you suddenly stop drinking alcohol, you may increase your risk of having seizures.
  • Do not drive a car or use heavy machinery until you know how Wellbutrin affects you. Wellbutrin can impair your ability to perform these tasks.

What are possible side effects of Wellbutrin?

Wellbutrin can cause serious side effects. Read this entire Medication Guide for more information about these serious side effects.

The most common side effects of Wellbutrin are nervousness, constipation, trouble sleeping, dry mouth, headache, nausea, vomiting, and shakiness (tremor).

If you have nausea, take your medicine with food. If you have trouble sleeping, do not take your medicine too close to bedtime.

These are not all the side effects of Wellbutrin. For a complete list, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Wellbutrin?

Store Wellbutrin at room temperature. Store out of direct sunlight. Keep Wellbutrin in its tightly closed bottle.

General Information about Wellbutrin

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Wellbutrin for a condition for which it was not prescribed. Do not give Wellbutrin to other people, even if they have the same symptoms you have. It may harm them. Keep Wellbutrin out of the reach of children.

This Medication Guide summarizes important information about Wellbutrin. For more information, talk to your doctor. You can ask your doctor or pharmacist for information about Wellbutrin that is written for health professionals.

What are the ingredients in Wellbutrin?

Active ingredient: bupropion hydrochloride.

Inactive ingredients: 75-mg tablet – D&C Yellow No. 10 Lake, FD&C Yellow No. 6 Lake, hydroxypropyl cellulose, hypromellose, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide; 100-mg tablet – FD&C Red No. 40 Lake, FD&C Yellow No. 6 Lake, hydroxypropyl cellulose, hypromellose, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide.

Tell your healthcare providers

Telemedicine does not replace your primary care physician. It is important to keep your primary care physician, other healthcare providers, and pharmacist informed of all medications you are taking, including those prescribed by your Mantra-affiliated provider, as they can interact with other medicines you may be taking.

Additional Resources

FDA Drug Safety Information: Bupropion Hydrochloride

FDA Access Data: Bupropion

Medline Plus: Bupropion